PLUMED is an open source library for free energy calculations in molecular systems which works together with some of the most popular molecular dynamics engines
. Free energy calculations can be performed as a function of many order parameters with a particular  focus on biological problems, using state of the art methods such as metadynamics, umbrella sampling and Jarzynski-equation based steered MD. The software, written in C++, can be easily interfaced with both fortran and C/C++ codes.

In May 2014 the second PLUMED tutorial and user meeting was held in Belfast, sponsored by CECAM. The material of the tutorial is included in PLUMED2 v.2.1!

In October 2013 we have released a completely redesigned version of the code: PLUMED2!

In June 2012 the first PLUMED meeting was held in Trieste, sponsored by SISSA!

In October 2010 the first PLUMED tutorial was held in Lausanne, sponsored by CECAM, and the project is still growing!

PLUMED is free software! To get the it click here

Recent News

  • PLUMED 2.1 and 2.0.4 are available for download
    it is a pleasure to announce two new PLUMED releases.

    Release 2.0.4 is a maintenance release on the 2.0.x branch with a few fixes, see:

    If you are using the keyword BIASVALUE with replica exchange you should upgrade to version 2.0.4 as soon as possible.

    Release 2.1.0 is a release that contains several new features, including a full tutorial, a reorganized manual with experimental PDF version, and several new collective variables, see: This version can now be considered as fully stable.

    We will still fix bugs in branch 2.0.x for a while, but users are encouraged to upgrade to the new 2.1.x release. Just read carefully the change log before upgrading.

    You can find both releases in the download section of the plumed webpage. They are also tagged on github (v2.0.4 and v2.1.0).
    Posted Sep 15, 2014, 11:57 PM by Carlo Camilloni
  • New releases: 2.0.3 and 2.1b
    Release 2.0.3 is a maintenance release on the 2.0.x branch and solves a few bugs, see:

    We encourage all the users to upgrade to this version.

    Release 2.1b is a brand new release that contains several new features, including a full tutorial, see:

    We invite users to try it and provide feedbacks. Among other things, we would like to have feedbacks on the new autoconf procedure (./configure script) so as to be sure that it is portable on a large number of different systems.

    You can find both releases in the download section of the plumed webpage. They are also tagged on git (v2.0.3 and v2.1b).

    For those of you using the master branch on git: you might want to switch to the v2.1 branch, since we will start soon to add possibly unstable features on the master branch.
    Posted Jul 1, 2014, 11:53 PM by Carlo Camilloni
  • PLUMED 2.0.2
    PLUMED version 2.0.2 is now available for download. Most important fixes from 2.0.1:
    • Fixed bug with METAD with INTERVAL and replica exchange, including bias exchange. Now the bias is correctly computed outside the boundaries. Notice that this is different from what was done in PLUMED 1.3. Also notice that INTERVAL now works correctly with grids and splines.
    • Fixed bug with READ and periodic variables.
    • Fixed bug with HISTOGRAM (option USE_ALL_DATA was not working properly).
    Moreover, there is a new patch for gromacs 4.6.5 that allows for a better load balancing when using GPUs.

    Especially because of the first fix, everyone using PLUMED 2.0 with bias exchange and INTERVAL is invited to upgrade.
    Posted Feb 11, 2014, 1:46 AM by Carlo Camilloni
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